Molecular Hydrogen Information

This is a static page listing publications that offer top-level looks at clinical uses of molecular hydrogen.

Overview of Hydrogen

Molecular hydrogen as a novel antioxidant: an overview of the advantages of hydrogen for medical applications. Shigeo Ohta; Methods Enzymol. 2015;555:289-317. doi: 10.1016/bs.mie.2014.11.038. Epub 2015 Jan 21. PMID: 25747486.

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases; (2017) Ge, L., Yang, M., Yang, N. N., Yin, X. X., & Song, W. G. .Oncotarget8(60), 102653–102673. https://doi.org/10.18632/oncotarget.21130

Beneficial biological effects and the underlying mechanisms of molecular hydrogen – a comprehensive review of 321 original articles, Masatoshi Ichihara 1, Sayaka Sobue 1, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno; Med Gas Res; 2015 Oct 19;5:12. doi: 10.1186/s13618-015-0035-1. eCollection 2015.

Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.; Sano M, Tamura T.; Curr Pharm Des. 2020 Dec 21. doi: Epub ahead of print. PMID: 33349213.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals; Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S.; Nat Med. 2007 Jun;13(6):688-94. doi: 10.1038/nm1577. Epub 2007 May 7. PMID: 17486089.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance Brandon J Dixon, Jiping Tang, John H Zhang; Med Gas Res: 2013 May 16

Hydrogen and COVID-19

COVID-19 and molecular hydrogen inhalation; Ostojic SM.; Advances in Respiratory Disease. January 2020.

Patient-Reported Health Outcomes After Treatment of COVID-19 with Nebulized and/or Intravenous Neutral Electrolyzed Saline Combined with Usual Medical Care Versus Usual Medical care alone: A Randomized, Open-Label, Controlled Trial. Delgado-Enciso I, Paz-Garcia J, Barajas-Saucedo CE, Mokay-Ramírez KA, et. al., Res Sq [Preprint]. 2020 Sep 10:rs.3.rs-68403. doi: 10.21203/rs.3.rs-68403/v1. PMID: 32935090; PMCID: PMC7491578.


What is Oxidative Stress? The movie. What IS Oxidative Stress? Simplistically speaking, oxidative stress is the result of normal cell functions. It’s the trash, and it’s created in every cell in our body. Molecular hydrogen “takes out the trash”. Watch the movie.

Oxidative Stress