Molecular Hydrogen and Sports

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Hydrogen water is the Designated water for Tokyo Olympics 2020 水素水(含氫水)是在東京奧運2020年指定飲用水。

Why did the 2021 Tokyo Olympics use hydrogen-rich water as designated water? H₂ Life, [Including this article is not a product endorsement.]

Memphis-made (hydrogen) water product helps Olympic athletes train during coronavirus pandemic WMC5 TV, By Cassie Carlson, May 17, 2020 [Including this article is not a product endorsement.]

5 reasons why athletes should drink hydrogen water by grace | Jan 20, 2021, Soyoshi International [Including this article is not a product endorsement.]

Research Publications

Should hydrogen therapy be included in a musculoskeletal medicine routine? Ostojic SM.F1000Res. 2016 Nov 10;5:2659. DOI: 10.12688/f1000research.9758.1. eCollection 2016.PMID: 28003879 Free PMC article. Molecular hydrogen (H (2)) has recently been recognized as a potential novel therapeutic agent in biomedicine. …

Application of Molecular Hydrogen as a Novel Antioxidant in Sports Science. Kawamura T, Higashida K, Muraoka I.Oxid Med Cell Longev. 2020 Jan 14;2020:2328768. DOI: 10.1155/2020/2328768. eCollection 2020.PMID: 32015786  Review: Molecular hydrogen (H(2)) is a colorless, tasteless, odorless, and minimal molecule with high flammability. …Most studies have reported the effects of H(2) on diseases such as cancer, diabetes, cerebral infarction, and Alzheimer’s disease. However, little i …

Molecular hydrogen in sports medicine: new therapeutic perspectives.Ostojic SM.Int J Sports Med. 2015 Apr;36(4):273-9. DOI: 10.1055/s-0034-1395509. Epub 2014 Dec 19.PMID: 25525953 Review. In particular, hydrogen therapy may be an effective and specific innovative treatment for exercise-induced oxidative stress and sports injury, with the potential for the improvement of exercise performance. This review will summarize recent research findings regarding t …

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes.LeBaron TW, Laher I, Kura B, Slezak J.Can J Physiol Pharmacol. 2019 Sep;97(9):797-807. DOI: 10.1139/cjp jp-2019-0067. Epub 2019 Apr 10.PMID: 30970215 Review. We review the biomedical effects of exercise and those of H(2), and we propose that hydrogen may act as an exercise mimetic and redox adaptogen, potentiate the benefits from beneficial exercise, and reduce the harm from noxious exercise. …

Recent Advances in Molecular Hydrogen Research Reducing Exercise-Induced Oxidative Stress and Inflammation. Nogueira JE, Branco LGS.Curr Pharm Des. 2021;27(5):731-736. DOI: 10.2174/1381612826666201113100245.PMID: 33185152 Physical exercise-induced oxidative stress and inflammation may be beneficial when exercise is a regular activity, but it is rather harmful when exercise is exhaustive and performed by unaccustomed organisms. Molecular hydrogen (H(2)) has recently appeared as a pote …

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study,  Toshio Mikamimikami@nms.ac.jp, Kohei Tano*, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, Tyler W. LeBaron, and Shigeo Ohtaohta@nms.ac.jp, Canadian Journal of Physiology and Pharmacology • 28 June 2019 • https://doi.org/10.1139/cjpp-2019-0059, Endurance, and fatigue were significantly improved in the H2 group as judged by maximal oxygen consumption and Borg’s scale, respectively. Taken together, drinking H2 water just before exercise exhibited anti-fatigue and endurance effects.

Short-term H2 inhalation improves running performance and torso strength in healthy adults. Javorac D, Stajer V, Ratgeber L, Betlehem J, Ostojic S.Biol Sport. 2019 Dec;36(4):333-339. DOI: 10.5114/biolsport.2019.88756. Epub 2019 Oct 31.PMID: 31938004

Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study. LeBaron TW, Larson AJ, Ohta S, Mikami T, Barlow J, Bulloch J, DeBeliso M.J Lifestyle Med. 2019 Jan;9(1):36-43. DOI: 10.15280/jlm.2019.9.1.36. Epub 2019 Jan 31.PMID: 30918832

Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study. Hori A, Sobue S, Kurokawa R, Hirano SI, Ichihara M, Hotta N.Med Gas Res. 2020 Oct-Dec;10(4):163-169. DOI: 10.4103/2045-9912.304223.PMID: 33380582, The various beneficial effects of the intake of molecular hydrogen (H2) have been demonstrated in the field of sports science. …

Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise, Michal Botek, Jakub Krejčí, Andrew J. McKune, Barbora Sládečková1, Nenad Naumovski2, DOI https://doi.org/10.1055/a-0991-0268 Published online: 2019
Int J Sports Med © Georg Thieme Verlag KG Stuttgart · New York ISSN 0172-4622, To conclude, acute pre-exercise supplementation with HRW reduced blood lactate at higher exercise intensities, improved exercise-induced perception of effort, and ventilatory efficiency. 

Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status.Nogueira JE, Passaglia P, Mota CMD, Santos BM, Batalhão ME, Carnio EC, Branco LGS.Free Radic Biol Med. 2018 Dec;129:186-193. DOI: 10.1016/j.freeradbiomed.2018.09.028. Epub 2018 Sep 19.PMID: 30243702Physical exercise induces inflammatory and oxidative markers production in the skeletal muscle and this process is under the control of both endogenous and exogenous modulators. Recently, molecular hydrogen (H(2)) has been described as a therapeutic gas able to reduced oxi …

Molecular and Cellular Mechanisms Associated with Effects of Molecular Hydrogen in Cardiovascular and Central Nervous Systems. Barancik M, Kura B, LeBaron TW, Bolli R, Buday J, Slezak J.Antioxidants (Basel). 2020 Dec 15;9(12):1281. DOI: 10.3390/antiox9121281.PMID: 33333951 Free PMC article. Review. The therapeutic potential of hydrogen is attributed to several major molecular mechanisms. This review focuses on the effects of hydrogen on the cardiovascular and central nervous systems, and summarizes current knowledge about its actions, including the regu …

The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial. LeBaron TW, Singh RB, Fatima G, Kartikey K, Sharma JP, Ostojic SM, Gvozdjakova A, Kura B, Noda M, Mojto V, Niaz MA, Slezak J.Diabetes Metab Syndr Obes. 2020 Mar 24;13:889-896. DOI: 10.2147/DMSO.S240122. eCollection 2020.PMID: 32273740 Free PMC article. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis. Molecular hydrogen (H(2)) may attenuate oxidative stress, improve cellular function, and reduce chronic inflammation. …

Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance Level. Botek M, Krejčí J, McKune AJ, Sládečková B.Int J Sports Physiol Perform. 2020 Feb 10:1-4. DOI: 10.1123/ijspp.2019-0507. Online ahead of print.PMID: 32045879PURPOSE: Hydrogen-rich water (HRW) has been shown to have an antifatigue effect. …A possible negative correlation was found between RT differences and average RT (r = -.79 to -.15). HRW for the 4 slowest runners (RT = 1490 [91] s) likely improved the RT (-36 to -3 …

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath. Kawamura T, Suzuki K, Takahashi M, Tomari M, Hara R, Gando Y, Muraoka I. Antioxidants (Basel). 2018 Sep 25;7(10):127. DOI: 10.3390/antiox7100127.PMID: 30257503 Free PMC article. The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H2) intake on these parameters. Nine healthy and …

Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men.Shibayama Y, Dobashi S, Arisawa T, Fukuoka T, Koyama K.Med Gas Res. 2020 Oct-Dec;10(4):155-162. DOI: 10.4103/2045-9912.304222.PMID: 33380581 Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. …

Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete [version 1; peer review: 2 approved], Javorac D, Stajer V, and Ostojic S. . F1000Research 2020, 9:245 (https://doi.org/10.12688/f1000research.22850.1) Our case has indicated that an acute multi-session hydrotherapy with hydrogen-rich water might be a helpful treatment in terms of pain, swelling reduction, and regaining range of motion after an ankle sprain.

Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial. Javorac D, Stajer V, Ratgeber L, Olah A, Betlehem J, Acs P, Vukomanovic B, Ostojic SM.Res Sports Med. 2020 Dec 27:1-9. DOI: 10.1080/15438627.2020.1868468. Online ahead of print.PMID: 33356580 Professional athletes (age 23.7 4.0 years; weight 78.6 5.7 kg, height 182.5 4.3 cm; professional experience 5.9 3.9 years) who incurred AAS during a sport-related activity were randomly assigned immediately after the injury to either hydrogen group (n = 9) or a conv …

Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury, Kenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, Kim M. Hansen, Gul N. Shah, Nader Sheibani, Therese Salameh, William A. Banks, PlosOne,  https://doi.org/10.1371/journal.pone.0108034 These studies were limited in that they did not evaluate mHW treatment without a pretreatment phase, but suggest that mHW could be an important, nontoxic treatment for acute TBI. Because of its nontoxicity and ease of administration, mHW could be readily adapted for clinical, emergency, and even first responder use.

 Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete [version 1; peer review: 2 approved]. Javorac D, Stajer V and Ostojic SM. F1000Research 2019, 8:1024 (https://doi.org/10.12688/f1000research.19739.1) This case has demonstrated that intensive consecutive therapy with oral transmucosal hydrogen formulation is a beneficial strategy with regard to the reduction of presence and severity of symptoms of sport-related mild TBI.