Molecular Hydrogen and COVID-19

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(C1) Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial, Wei-Jie Guan, Chun-Hua Wei, Ai-Lan Chen, Xiao-Cong Sun, Guang-Yun Guo, Xu Zou, Jin-Dong Shi, Pei-Zhen Lai, Ze-Guang Zheng, Nan-Shan Zhong, J Thorac Dis. 2020 Jun;12(6):3448-3452. DOI: 10.21037/jtd-2020-057. PMID: 32642277PMCID: PMC7330772 DOI: 10.21037/jtd-2020-057

An open-label multicenter clinical trial, between January 21st and March 23rd, 2020, was conducted using hospitalized laboratory-confirmed COVID-19 patients ranging in age from 18–85 years and all having difficulty breathing both on hospital admission and at enrollment in this study. This is the first multicenter randomized clinical trial that verifies the efficacy and safety of H2-O2inhalation in patients with COVID-19. The clinical benefits were likely to be attributable to the ability of H2-O2 to decrease the inspiratory efforts due to the significantly lower resistance when passing through the respiratory tract compared with room air. Patients with COVID-19 frequently presented with dyspnea, coughing, chest pain and distress, and oxygen desaturation, which cannot be rapidly ameliorated with other existing therapies (including oxygen therapy). The therapeutic effects of H2-O2 became significant as early as days 2 and 3 and the amelioration of most respiratory symptoms persisted till the end-of-treatment, which again cannot be readily interpreted by miscellaneous supportive therapies including oxygen therapy.

(C2) The use of ultrapure molecular hydrogen enriched with atomic hydrogen in apparatuses of artificial lung ventilation in the fight against virus COVID-19, Zolotarenko AnD et al., International Journal of Hydrogen Energy,

When electrolyzers are used to produce an oxygen-hydrogen mixture, alkaline mist and other impurities can enter the patient’s lungs and cause poisoning and chemical burns. For this reason, the use of atomic hydrogen obtained from metal hydride sources for ventilation of the lungs will be more effective for treating COVID-19 than a molecular hydrogen-oxygen mixture from an electrolyzer.

(C3) Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients, Front. Pharmacol., 15 October 2020 |

“In summary, we hypothesize that the early use of hydrogen might mitigate the destruction caused by the cytokine storm associated with COVID-19, reducing lung injury, promoting viscous sputum drainage, and thus reducing the incidence of critically ill patients. Only one other article to date has mentioned the use of hydrogen to treat COVID-19 patients (Guan et al., 2020). In the future, more large-scale randomized controlled trials are needed to verify the efficacy and safety of this treatment clinically.”

(C4) Molecular Hydrogen Therapy For Management Of COVID-19, Ministry of Health, Malaysia Rapid Assessment.

[An overview of the clinical uses of molecular hydrogen displayed by Disease/pathological and physiological condition under study, Method of administration, Outcomes, and Authors’ conclusion.]

(C5) – COVID-19 and Hydrogen Clinical trials as current at 03/18/2021

PubMed Search: “Molecular Hydrogen” AND COVID

19 and molecular hydrogen inhalation.
Ostojic SM.Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620951051. doi: 10.1177/1753466620951051.PMID: 32865158 

Hydrogen: A Potential New Adjuvant Therapy for COVID19 Patients.Yang F, Yue R, Luo X, Liu R, Huang X.Front Pharmacol. 2020 Oct 15;11:543718. doi: 10.3389/fphar.2020.543718. eCollection 2020.PMID: 33178011

Based on a review of the research, the use of hydrogen might reduce the destructive cytokine storm and lung injury caused by SARSCoV2 during COVID19 (Corona Virus Disease 2019) in the early stage, stimulating ropy sputum drainag …

Molecular hydrogen (H(2) ) as a potential treatment for acute and chronic fatigue.Lucas K, Rosch M, Langguth P.Arch Pharm (Weinheim). 2021 Apr;354(4):e2000378. doi: 10.1002/ardp.202000378. Epub 2020 Dec 23.PMID: 33368699

Acute fatigue develops frequently after physical exercise or after alcohol hangover, whereas microbial infections such as influenza or COVID19 and chronic diseases like Parkinson’s disease or multiple sclerosis are often associated with chronic fatigue. …

Chemical and Biochemical Aspects of Molecular Hydrogen in Treating Kawasaki Disease and COVID19.Chen KD, Lin WC, Kuo HC.Chem Res Toxicol. 2021 Mar 15. doi: 10.1021/acs.chemrestox.0c00456. Online ahead of print. PMID: 33719401

Kawasaki disease (KD) is a systemic vasculitis and is the most commonly acquired heart disease among children in many countries, which was first reported 50 years ago in Japan. The 2019coronavirus disease (COVID19severeacuterespi …5CiteShare 

Direct Targets and Subsequent Pathways for Molecular Hydrogen to Exert Multiple Functions: Focusing on Interventions in Radical Reactions.Ohta S.Curr Pharm Des. 2021;27(5):595-609. doi: 10.2174/1381612826666200806101137.PMID: 32767925 

Review.Molecularhydrogen (H(2)) was long regarded as non-functional in mammalian cells. …The resulting suppression of Ca2+-signaling inactivates multiple functional NFAT and CREB transcription factors, which may explain H(2) multi-functionality. This revie …

The Use Of Ultrapure Molecular Hydrogen Enriched With Atomic Hydrogen In Apparatuses Of Artificial Lung Ventilation In The Fight Against Virus COVID19.Zolotarenko AD, Zolotarenko AD, Veziroglu A, Veziroglu TN, Shvachko NA, Pomytkin AP, Gavrylyuk NA, Schur DV, Ramazanov TS, Gabdullin MT.Int J Hydrogen Energy. 2021 Mar 14. doi: 10.1016/j.ijhydene.2021.03.025. Online ahead of print.PMID: 33746342

COVID19 is a disease caused by the SARSCoV virus. It stands for severeacuterespiratorysyndrome, which affects the lungs. …For this reason, the use of atomic hydrogen obtained from metal hydride sources for vent …

Low-Flow Nasal Cannula Hydrogen Therapy.Sano M, Shirakawa K, Katsumata Y, Ichihara G, Kobayashi E.J Clin Med Res. 2020 Oct;12(10):674-680. doi: 10.14740/jocmr4323. Epub 2020 Sep 21.PMID: 33029275 Free PMC article.

BACKGROUND: Molecularhydrogen (H(2)) is a biologically active gas that is widely used in the healthcare sector. …Therefore, this study aimed to evaluate blood concentrations of H(2) delivered from an H(2) gas generator via a nasal cannula. ME …

Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress.Hirano SI, Ichikawa Y, Sato B, Yamamoto H, Takefuji Y, Satoh F.Int J Mol Sci. 2021 Mar 4;22(5):2549. doi: 10.3390/ijms22052549.PMID: 33806292 

Review.Mitochondria are the largest source of reactive oxygen species (ROS) and are intracellular organelles that produce large amounts of the most potent hydroxyl radical (OH). Molecularhydrogen (H(2)) can selectively eliminate OH generated inside of the mitochond …