Table 2 Disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants (321 original articles published in English) for which the effects of hydrogen have been reported from 2007 to June 2015
From: Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles –https://medicalgasresearch.biomedcentral.com/articles/10.1186/s13618-015-0035-1
See the list of referenced publications below or click links to be redirected to article.
Diseases and conditions | References |
---|---|
Brain | |
Cerebrovascular diseases (CVD) | |
Cerebral I/R injury | [1, 10, 56, 83, 94, 99–109] |
Hypertensive stroke | [110] |
Brain injury secondary to intracerebral hemorrhage | [28] |
Subarachnoid hemorrhage | [48, 61, 66, 73, 111–113] |
Brain injury other than CVD | |
Traumatic brain injury | [114–118] |
Deep hypothermic circulatory arrest-induced brain damage | [57] |
Neurodegenerative diseases | |
Parkinson’s disease | [11, 95–97, 119] |
Alzheimer’s disease | [43, 120] |
Others | |
Restraint-induced dementia | [121] |
Senile dementia in senescence-accelerated mice | [122] |
LPS-induced neuroinflammation | [81, 123] |
Oxidative stress-induced neuronal cell damage | [124, 125] |
Spinal Cord and peripheral nerve | |
Spinal cord I/R injury | [126, 127] |
Spinal cord injury | [77, 128] |
Neuropathic pain | [39, 92, 129, 130] |
Hyperalgesia | [79, 131, 132] |
Eye | |
Retinal I/R injury | [133, 134] |
Diabetic retinopathy | [135, 136] |
Hyperoxia-induced retinopathy | [137] |
Light-induced retinopathy | [138, 139] |
Glutamine-induced retinopathy | [50] |
S-nitroso-N-acetylpenicillamine-induced retinopathy | [140] |
Optic nerve crush | [141] |
Selenite-induced cataract | [142] |
Corneal alkali-burn | [55] |
Anti-inflammatory effects on LPS-activated retinal microglia cells | [64] |
Ear | |
Hearing loss | [143–148] |
Cisplatin-induced ototoxicity | [149, 150] |
Ouabain-induced ototoxicity | [151] |
Oral Cavity | |
Periodontitis | [32] |
Periodontal oxidative damage | [152] |
Lung | |
Lung I/R injury | [153, 154] |
Oxygen-induced lung injury | [82, 155, 156] |
Ventilation-induced lung injury | [53, 157] |
LPS-induced acute lung injury | [13, 14, 16, 158] |
Intestinal I/R-induced lung injury | [159] |
Burn-induced lung injury | [160] |
Paraquat-induced lung injury | [161, 162] |
igarette smoking lung injury | [163] |
Smoke inhalation lung injury | [74] |
Pulmonary hypertension | [78, 164] |
Heart | |
Myocardial infarction and I/R injury | [17–24, 84] |
Diabetic cardiomyopathy | [40] |
Sleep apnea-induced left ventricular remodeling | [165, 166] |
Ventricular hypertrophy | [167] |
Stomach | |
Stress-induced gastric ulceration | [38] |
Aspirin-induced gastric ulceration | [168, 169] |
Intestine | |
Intestinal I/R injury | [170, 171] |
Ulcerative colitis | [172, 173] |
Colon inflammation | [174] |
Sepsis-induced intestinal injury | [87] |
Necrotizing enterocolitis | [175] |
Liver | |
Liver I/R injury | [71, 98, 176–178] |
Chronic hepatitis B | [179] |
Nonalcoholic steatohepatitis | [180] |
Liver injury induced by massive hepatectomy | [67, 93, 181] |
Liver injury induced by obstructive jaundice | [31] |
Liver injury induced by endotoxin | [35] |
Liver injury induced by acetaminophen | [47] |
Liver injury induced by carbon tetrachloride | [42] |
Liver injury induced by concanavalin A | [182] |
Liver cirrhosis | [183] |
Liver fibrosis | [184] |
Pancreas | |
Acute pancreatitis | [76, 185–187] |
Peritoneum | |
Acute peritonitis | [68] |
Kidney | |
Renal I/R injury | [188–190] |
Acute renal injury | [37, 72, 191–194] |
Hypertensive renal injury | [69] |
Cisplatin-induced nephropathy | [195–197] |
Gentamicin-induced nephrotoxicity | [198] |
Inhibition of AGEs production | [199] |
Renal calcium deposition | [200] |
Bladder | |
Interstitial cystitis | [201] |
Reproductive organ | |
Testicular I/R injury | [202, 203] |
Erectile dysfunction | [204] |
Nicotine-induced testicular oxidative stress | [205] |
Cigarette smoke-induced testicular damage | [206] |
Skin | |
I/R injury | [46, 207] |
UV-induced skin injury | [45, 208–211] |
Acute erythematous skin disease | [212] |
Atopic dermatitis | [213, 214] |
Psoriasis | [215] |
Pressure ulcer | [216] |
Burn | [49, 70] |
Arsenic toxicity | [217] |
Bone and Joint | |
Rheumatoid arthritis | [218, 219] |
Osteoporosis | [36, 62] |
Bone loss induced by microgravity | [34] |
TNFα-induced osteoblast injury | [220] |
NO-induced cartilage toxicity | [221] |
Skeletal Muscle and soft tissue | |
I/R injury in skeletal muscle | [222] |
Inflammatory and mitochondrial myopathies | [223] |
Muscle fatigue | [224] |
Sports-related soft tissue injury | [225] |
Blood vessel | |
Atherosclerosis | [58, 59, 85, 226, 227] |
AGEs-induced blood vessel damage | [228] |
Neointimal hyperplasia | [29] |
Hyperplasia in arterialized vein graft | [229] |
Vascular dysfunction | [60] |
Vascular endothelial function | [230] |
Blood and Bone Marrow | |
Aplastic anemia | [231] |
Maintenance of multipotential stroma/mesenchymal stem cells | [232] |
Neutrophil function | [233] |
Inhibition of collagen-induced platelet aggregation | [234] |
Improvement of blood fluidity | [235] |
Metabolism | |
Diabetes mellitus | [236–241] |
Hyperlipidemia | [44, 242–244] |
Metabolic syndrome | [245–247] |
Metabolic process-related gene expression | [248] |
Oxidized low density lipoprotein-induced cell toxicity | [54] |
Serum alkalinization | [249] |
Exercise-induced metabolic acidosis | [250] |
Inflammation/Allergy | |
Sepsis | [41, 86, 251–255] |
LPS/IFNγ-induced NO production | [27] |
LPS-induced inflammatory response | [90] |
LPS-induced vascular permeability | [80, 256] |
Zymosan-induced inflammation | [257] |
Carrageenan-induced paw edema | [258] |
Inflammatory response of cardiopulmonary bypass | [259] |
Type I allergy | [26] |
Asthma | [63] |
Perinatal Disorders | |
Neonatal cerebral hypoxia | [260–263] |
LPS-induced fetal lung injury | [15] |
Preeclampsia | [264, 265] |
Cancer | |
Growth of tongue carcinoma cells | [266] |
Fe-NTA-induced nephrotoxicity and tumor progression | [65] |
Radiation-induced thymic lymphoma | [267] |
Tumor angiogenesis | [268] |
Enhancement of 5-FU antitumor efficacy | [269] |
Radiation | |
Cardiac damage | [270] |
Lung damage | [271] |
Testicular damage | [272] |
Skin damage | [273, 274] |
Germ, hematopoietic and other cell damage | [275–280] |
Radiation-induced adverse effects | [281] |
Radiation-induced immune dysfunction | [282] |
Intoxication | |
Carbon monoxide | [283–286] |
Sevoflurane | [287, 288] |
Doxorubicin-induced heart failure | [289] |
Melamine-induced urinary stone | [290] |
Chlorpyrifos-induced neurotoxicity | [291] |
Transplantation | |
Heart | [52, 292–294] |
Lung | [33, 88, 295–299] |
Kidney | [30, 51] |
Intestine | [89, 300, 301] |
Pancreas | [302] |
Osteochondral grafts | [303] |
Acute GVHD | [304, 305] |
Resuscitation | |
Cardiac arrest | [306, 307] |
Hemorrhagic shock | [75, 308, 309] |
Dialysis | |
Hemodialysis | [310–313] |
Peritoneal dialysis | [314, 315] |
Others | |
Lifespan extension | [316] |
Sperm motility | [317] |
Decompression sickness | [318] |
Genotoxicity and mutagenicity | [319] |
Plant | |
Root organogenesis | [91, 320] |
Salt tolerance | [321, 322] |
Postharvest ripening | [323] |
Stomatal closure | [324] |
Radish sprout tolerance to UVA | [325] |
High light stress | [326] |
Phytohormone signaling and stress responses | [327] |
Tolerance to paraquat-induced oxidative stress | [328] |
Cadmium toxicity | [329, 330] |
Mercury toxicity | [331] |
References
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