Diseases and Conditions Found Responsive to Molecular Hydrogen Treatment

Table 2 Disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants (321 original articles published in English) for which the effects of hydrogen have been reported from 2007 to June 2015

From: Beneficial biological effects and the underlying mechanisms of molecular hydrogen – comprehensive review of 321 original articles –https://medicalgasresearch.biomedcentral.com/articles/10.1186/s13618-015-0035-1

See the list of referenced publications below or click links to be redirected to article.

Diseases and conditionsReferences
Cerebrovascular diseases (CVD) 
 Cerebral I/R injury[11056839499109]
 Hypertensive stroke[110]
 Brain injury secondary to intracerebral hemorrhage[28]
 Subarachnoid hemorrhage[48616673111113]
Brain injury other than CVD 
 Traumatic brain injury[114118]
 Deep hypothermic circulatory arrest-induced brain damage[57]
Neurodegenerative diseases 
 Parkinson’s disease[119597119]
 Alzheimer’s disease[43120]
 Restraint-induced dementia[121]
 Senile dementia in senescence-accelerated mice[122]
 LPS-induced neuroinflammation[81123]
 Oxidative stress-induced neuronal cell damage[124125]
Spinal Cord and peripheral nerve 
 Spinal cord I/R injury[126127]
 Spinal cord injury[77128]
 Neuropathic pain[3992129130]
 Retinal I/R injury[133134]
 Diabetic retinopathy[135136]
 Hyperoxia-induced retinopathy[137]
 Light-induced retinopathy[138139]
 Glutamine-induced retinopathy[50]
 S-nitroso-N-acetylpenicillamine-induced retinopathy[140]
 Optic nerve crush[141]
 Selenite-induced cataract[142]
 Corneal alkali-burn[55]
 Anti-inflammatory effects on LPS-activated retinal microglia cells[64]
 Hearing loss[143148]
 Cisplatin-induced ototoxicity[149150]
 Ouabain-induced ototoxicity[151]
Oral Cavity 
 Periodontal oxidative damage[152]
 Lung I/R injury[153154]
 Oxygen-induced lung injury[82155156]
 Ventilation-induced lung injury[53157]
 LPS-induced acute lung injury[131416158]
 Intestinal I/R-induced lung injury[159]
 Burn-induced lung injury[160]
 Paraquat-induced lung injury[161162]
 igarette smoking lung injury[163]
 Smoke inhalation lung injury[74]
 Pulmonary hypertension[78164]
 Myocardial infarction and I/R injury[172484]
 Diabetic cardiomyopathy[40]
 Sleep apnea-induced left ventricular remodeling[165166]
 Ventricular hypertrophy[167]
 Stress-induced gastric ulceration[38]
 Aspirin-induced gastric ulceration[168169]
 Intestinal I/R injury[170171]
 Ulcerative colitis[172173]
 Colon inflammation[174]
 Sepsis-induced intestinal injury[87]
 Necrotizing enterocolitis[175]
 Liver I/R injury[7198176178]
 Chronic hepatitis B[179]
 Nonalcoholic steatohepatitis[180]
 Liver injury induced by massive hepatectomy[6793181]
 Liver injury induced by obstructive jaundice[31]
 Liver injury induced by endotoxin[35]
 Liver injury induced by acetaminophen[47]
 Liver injury induced by carbon tetrachloride[42]
 Liver injury induced by concanavalin A[182]
 Liver cirrhosis[183]
 Liver fibrosis[184]
 Acute pancreatitis[76185187]
 Acute peritonitis[68]
 Renal I/R injury[188190]
 Acute renal injury[3772191194]
 Hypertensive renal injury[69]
 Cisplatin-induced nephropathy[195197]
 Gentamicin-induced nephrotoxicity[198]
 Inhibition of AGEs production[199]
 Renal calcium deposition[200]
 Interstitial cystitis[201]
Reproductive organ 
 Testicular I/R injury[202203]
 Erectile dysfunction[204]
 Nicotine-induced testicular oxidative stress[205]
 Cigarette smoke-induced testicular damage[206]
 I/R injury[46207]
 UV-induced skin injury[45208211]
 Acute erythematous skin disease[212]
 Atopic dermatitis[213214]
 Pressure ulcer[216]
 Arsenic toxicity[217]
Bone and Joint 
 Rheumatoid arthritis[218219]
 Bone loss induced by microgravity[34]
 TNFα-induced osteoblast injury[220]
 NO-induced cartilage toxicity[221]
Skeletal Muscle and soft tissue 
 I/R injury in skeletal muscle[222]
 Inflammatory and mitochondrial myopathies[223]
 Muscle fatigue[224]
 Sports-related soft tissue injury[225]
Blood vessel 
 AGEs-induced blood vessel damage[228]
 Neointimal hyperplasia[29]
 Hyperplasia in arterialized vein graft[229]
 Vascular dysfunction[60]
 Vascular endothelial function[230]
Blood and Bone Marrow 
 Aplastic anemia[231]
 Maintenance of multipotential stroma/mesenchymal stem cells[232]
 Neutrophil function[233]
 Inhibition of collagen-induced platelet aggregation[234]
 Improvement of blood fluidity[235]
 Diabetes mellitus[236241]
 Metabolic syndrome[245247]
 Metabolic process-related gene expression[248]
 Oxidized low density lipoprotein-induced cell toxicity[54]
 Serum alkalinization[249]
 Exercise-induced metabolic acidosis[250]
 LPS/IFNγ-induced NO production[27]
 LPS-induced inflammatory response[90]
 LPS-induced vascular permeability[80256]
 Zymosan-induced inflammation[257]
 Carrageenan-induced paw edema[258]
 Inflammatory response of cardiopulmonary bypass[259]
 Type I allergy[26]
Perinatal Disorders 
 Neonatal cerebral hypoxia[260263]
 LPS-induced fetal lung injury[15]
 Growth of tongue carcinoma cells[266]
 Fe-NTA-induced nephrotoxicity and tumor progression[65]
 Radiation-induced thymic lymphoma[267]
 Tumor angiogenesis[268]
 Enhancement of 5-FU antitumor efficacy[269]
 Cardiac damage[270]
 Lung damage[271]
 Testicular damage[272]
 Skin damage[273274]
 Germ, hematopoietic and other cell damage[275280]
 Radiation-induced adverse effects[281]
 Radiation-induced immune dysfunction[282]
 Carbon monoxide[283286]
 Doxorubicin-induced heart failure[289]
 Melamine-induced urinary stone[290]
 Chlorpyrifos-induced neurotoxicity[291]
 Osteochondral grafts[303]
 Acute GVHD[304305]
 Cardiac arrest[306307]
 Hemorrhagic shock[75308309]
 Peritoneal dialysis[314315]
 Lifespan extension[316]
 Sperm motility[317]
 Decompression sickness[318]
 Genotoxicity and mutagenicity[319]
 Root organogenesis[91320]
 Salt tolerance[321322]
 Postharvest ripening[323]
 Stomatal closure[324]
 Radish sprout tolerance to UVA[325]
 High light stress[326]
 Phytohormone signaling and stress responses[327]
 Tolerance to paraquat-induced oxidative stress[328]
 Cadmium toxicity[329330]
 Mercury toxicity[331]



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