Smoking, vaping and hospitalization for COVID-19 – Article (Preprint v13) | Qeios

Now is not the time to quit smoking. “Smoke ‘um if you got ‘um.  Empirical evidence derived from a study of studies published in PubMed indicates smoking reduces lung injury by a coronavirus.  
“More recent analyses suggest that up-regulation of ACE-2 caused by smoking could be detrimental for COVID-19.4,5 However experimental data suggest that infection with SARS-CoV and SARS-CoV-2 leads to down-regulation of ACE2, and this downregulation is detrimental due to uncontrolled ACE and angiotensin II activity.6,7 It has been observed that decreased ACE2 availability contributes to lung injury and ARDS development.8,9 Therefore, higher ACE2 expression, while seemingly paradoxical, may protect against acute lung injury caused by COVID-19.10